Researchers successfully demonstrated the efficacy of adeno-associated virus (AAV) vectors in reversing genetic hearing loss in aged animal models. The scientists developed a mature mouse model with a mutation similar to the human TMPRSS3 gene defect, which typically results in progressive hearing loss.

Upon injecting these mice with an AAV carrying a healthy TMPRSS3 gene, a notable restoration of hearing was observed. This advancement suggests the potential of gene therapies to treat genetic hearing loss, even in advanced age.

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